How is it possible that, in an era of unprecedented medical progress, humanity is once again caught in a major pandemic? Several lines of evidence suggest that advances in infectious diseases control facilitate the development of major urban centers, global high-speed transportation, industrial animal farming and ecosystem destruction. In turn, all of these are well known to favor such diseases, thus reproducing the same kind of dynamic previously observed in resource consumption and known as “Jevons’ paradox”. Such economic developments compel health systems to develop continuously just to maintain the improvements that had already been achieved, which, furthermore, became more difficult with the generalization of neoliberal policies. In this process, progresses whose primary purpose is to benefit everybody’s health are transmuted into benefits for those involved in certain economic activities. This is especially apparent in the case of long-haul aviation, a profitable activity aimed mainly at a high-income minority but playing a unique role in disease transmission. The COVID-19 pandemic is, therefore, one of the most massive cost-shifting events ever. A proposal is presented to prevent comparable if not even more harmful events in the future, with two parts. First, a global fund with base funding from an internationally-agreed tax on aviation, devoted to upgrading health systems and to programs to tackle sources of emerging infectious diseases, especially wild animal trade. Second and no less important, a global agreement to fundamentally transform agri-food systems.